show add
hide add

Compositions and methods for promoting hair growth


Patent:

United States Patent   5,407,944

Goldman    Apr. 18, 1995

Inventors:

Goldman; Boris E. (2019 Breton, S.E., Grand Rapids, MI 49546).

Appl. No:

020,202

Filed:

Feb. 19, 1993

Abstract:

The present invention provides compositions and methods for promoting hair growth. The methods generally comprise the administration to a patient of a therapeutically effective amount of the compositions of the present invention which employ a vasodilator in combination with estradiol and/or a 5-.alpha.-reductase inhibitor in a pharmaceutically acceptable vehicle. The compositions and methods of the present invention are suitable for the treatment of baldness, in particular, male pattern baldness.

36 Claims, 4 Drawing Figures

 

References Cited:

U.S. Patent Documents

4,596,812     Jun, 1986     Chidsey, III et al.     514/256

5,015,470     May, 1991     Gibson     424/70

Other References

Hamilton, J. B., “Male Hormone Stimulation is Prerequisite and an Incitant in Common Baldness.” Am J. Anat. 71:451-480 (1942).

Jonsson, K. et al., “Tissue Oxygenation, Anemia, and Perfusion in Relation to Wound Healing in Surgical Patients,” Ann. Surg. 214, 5:605-613 (1991).

Bruchovsky, N. et al., “The Conversion of Testosterone to 5 .alpha.-Androstan-17 .beta.-ol-3-one Rat Prostate in Vivo and in Vitro*,” J. Biol. Chem. 243:2012 (1968).

Fang, S. et al., “Receptor Proteins for Androgens,” J. Biol. Chem. 244:6584 (1969).

Thigpen, A. E. et al., “Tissue Distribution and Ontogeny of Steroid 5 Alpha-Redustase Isozyme Expression,” J. Clin. Invest. 92(2):903-10 (1993).

Mellin, T. N. et al., “Azasteroids as Inhibitors of Testosterone 5 Alpha-Redustase in Mammalian Skin,” J. Steroid Biochem. Mol. Biol. 44(2):121-31 (1993).

Imperato-McGinley, J. et al., “The Androgen Control of Sebum Production. Studies of Subjects with Dihydrotestosterone Deficiency and Complete Androgen Insensitivity,” J. Clin. Endocrinol. Metab. 76(2):524-8 (1993).

Diani, A. R. et al., “Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque,” J. Clin. Endocrinol. Metab. 74(2):345-50 (1992).

Young, M. W., “American Association of Anatomists,” Anatomical Record 100:728 (1948).

Young, M. W., “American Association of Anatomists,” Anatomical Record 97:378 (1947).

Szasz, T. S. et al. “A Theory of the Pathogenesis of Ordinary Human Baldness” Archives of Dermatology and Syphilology 61:34-48 (1950).

Orentreich, N. “Autografts in Alopecias and Other Selected Dermatological Conditions,” Ann. NY Acad. Sci. 83:463-479 (1959).

Orentreich, N. et al. “Biology of Scalp Hair Growth,” Clin. Plast. Surg. 9:197:205 (1982).

Zapocosta, A. R. “Reversal of Baldness in Patient Receiving Minoxidil for Hypertension,” New Eng. J. Med. 303:1480-1481 (1980).

Hamilton, J. B. “Patterned Loss of Hair in Man: Types and Incidence,” Ann. NY Acad. Sci. 53:709:728 (1951).

Klemp. P. et al., “Subcutaneous Blood Flow in Early Male Pattern Baldness,” J. Invest. Derm. 92(5):725-726 (1989).

Juri, J. et al. “Temporo-Parieto-Occipital Flap for the Treatment of Baldness,” Clin. Plas. Surg. 9:255-261 (1982).

Lemke, R. et al., “Noninvasive Ptco(2) Initial Slope Index and Invasive Ptco(2) Arterial Index as Diagnostic Criterion of the State of Peripheral Circulation,” Crit. Care Med. 16:353-357 (1988).

Kram, H. B. et al., “Assessment of Peripheral Vascular Disease by Postocclusive Transcutaneous Oxygen Recovery Time,” J. Vasc. Surg. 1:628-634 (1984).

Wester, R. C. et al., “Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography,” J. Invest. Derm. 82:515-517 (1984).

Dingman, R. O. et al., “The Surgical Repair of Traumatic Defects of the Scalp,” Clin. Plast. Surg. 9:131-144 (1982).

Hunt, et al., “The Effect of Varying Ambient Oxygen Tensions on Wound Metabolism and Collagen Synthesis,” Surg. Gyn. Ob. 135:561-566 (1972).

Marshall, R. C. et al., “Structure and Biochemistry of Mammalian Hard Keratin,” 4:47-83 (1991).

Buxman, M. et al., “Keratin Cross-Linking and Epidermal Transglutaminase,” J. Invest. Derm. 65:107-112 (1975).

Buxman, M. M., “Enzymes of Keratinization,” Internat. J. Derm. 20:95-98 (1981).

Sawaya, M. E. et al., “Immunohistochemical Distribution of Aromatase and 3B-hydroxysteroid Dehydrogenase in Human Hair Follicle and Sebaceous Gland,” J. Cutan. Pathol. 19:309-314 (1992).

Sawaya, M. E. “Steroid Chemistry and Hormone Controls During the Hair Follicle Cycle,” Ann. NY Acad. Sci. 642:376-383 (1991) and (Abstract).

Schweikert, H. U. et al., “Regulation of Human Hair Growth by Steroid Hormones. 1. Testosterone Metabolism in Isolated Hairs,” J. Clin. Endocrin. Metab. 38:811-819 (1974).

Orfanos, C. E. “Lokaltherapie der Alopecia Androgentica mit 17 .alpha.-Ostradiol,” Dermatologica 161:124-132 (1980).

Takayasu, S. et al., “The Conversion of Testosterone to 17.beta.-hydroxy-5.alpha.-androstan-3-one (Dihydrotestosterone) by Human Hair Follicles,” J. Clin. Endocrinol. Metab. 34:1098 1101(1972).

Anderson, R. D., “Expansion-Assisted Treatment of Male Pattern Baldness,” Clin. Plast. Surg. 14:477-489 (1987).

Herring, B. D., “Unravelling the Pathophysiology of Male Pattern Baldness,” J. Nation. Med. Assoc. 77:142 and 145 (1985).

Freedberg, I. M., “Biochemistry of Keratinization in Hair: Protein Synthesis, Pathways and Controls,” pp. 105-112 (1987).

Hamilton, J. B., Am. J. Anat. 71:451-480 (1942).

Tang, S. et al., J. Biol. Chem. 244:6584 (1969).
Primary Examiner: Prescott; Arthur C.
Attorney, Agent or Firm: Harness, Dickey & Pierce




READ THIS NEXT

    Shampoo for Women

    Blonde girl worried about hair loss

    ProTHIK Spray

    Tagamet (Cimetidine)

    Hair Loss Treatment

    man controls hair loss and unhappy gazing at you in the mirror 685775544 bald, baldness, loosing, prevention, hearttrob

    Male Pattern Alopecia

    Pin It on Pinterest

    Share This