United States Patent 5,510,351
Graham, et al. Apr. 23, 1996
17-Ethers and thioethers of 4-aza-steroids. Asteroids as 5A-reductase inhibitors.
Inventors:
Graham; Donald W. (Mountainside, NJ); Aster; Susan D. (Teaneck, NJ); Hagmann; William (Westfield, NJ); Tolman; Richard L. (Warren, NJ).
Assignee:
Merck & Co., Inc. (Rahway, NJ).
Notice:
The portion of the term of this patent subsequent to Nov. 10, 2014 has been disclaimed
Appl. No:
338,490
Filed:
Nov. 14, 1994
Related U.S. Application Data:
Continuation-in-part of Ser No. 886,021, May 20, 1992, abandoned.
Intl. Cl.: A61K 31/58
Current U.S. Cl.: 514/253; 514/241; 514/261; 514/269; 514/284; 544/198; 544/242; 544/264; 544/336; 546/77
Field of Search: 546/77; 514/284, 253; 544/336
Abstract:
Described are delta 17 and delta 20 olefinic and saturated 17 Beta-substituted 4-aza-5 alpha-androstan-3-ones and related compounds having 5 alpha reductase inhibitors for treatment of benign prostatic hyperplasia and other hyperandrogenic related disorders.
14 Claims, No Drawings
References Cited:
U.S. Patent Documents
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Other References
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Primary Examiner: Daus; Donald G.
Attorney, Agent or Firm: Fitch; Catherine D., Giesser; Joanne M., Winokur; Melvin
