United States Patent 5,538,945
Pallenberg, et al. Jul. 23, 1996
Method of promoting hair growth.
Inventors:
Pallenberg; Alexander J. (Duval, WA); Patt; Leonard M. (Seattle, WA); Trachy; Ronald E. (Bothell, WA).
Assignee:
ProCyte Corporation (Kirkland, WA).
Appl. No:
261,475
Filed:
Jun. 17, 1944
Intl. Cl.: A61K 38/04
Current U.S. Cl.: 514/6; 514/18; 514/19; 530/304
Field of Search: 514/6, 18, 19; 530/304
Abstract:
Peptide-copper complexes are disclosed which stimulate the growth of hair on warm-blooded animals. In one aspect of this invention, the peptide-copper complexes are dipeptides or tripeptides chelated to copper at a molar ratio ranging from about 1:1 to 3:1, with the second position of the peptide from the amino terminus being histidine, arginine or a derivative thereof. The peptide-copper complexes may be formulated for administration by, for example, topical application or injection. Any affliction associate with hairloss, including hairloss associated with both androgenetic and secondaryalopecia, may be treated with the peptide-copper complexes of this invention.
12 Claims, No Drawings
References Cited:
U.S. Patent Documents
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Foreign Patent Documents
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Other References
Uno, H. et al. Macaque and Rodent Models for the Screening of Drugs for Stimulating Hair Growth. Journal of Cutaneous Aging and Cosmetic Dermatology 1, 193-204 (1990).
Metzler, D. “Biochemistry”, Academic Press, NY (1977). See p. 198 Table 4-2 .
Primary Examiner: Nucker; Christine M.
Assistant Examiner: Prickril; Benet
Attorney, Agent or Firm: Seed and Berry
