Human prostatic steroid 5 alpha-reductase isoforms–a comparative study of selective inhibitors

Abstract: The present study describes the independent expression of the type 1 and 2 isoforms of human 5 alpha-reductase in […]

Testosterone metabolism in primary cultures of human prostate epithelial cells and fibroblasts

Abstract: We compare testosterone (T) metabolism in primary cultures of epithelial cells and fibroblasts separated from benign prostate hypertrophy (BPH) […]

Several selective protein kinase C inhibitors including procyanidins promote hair growth

Abstract: We have previously reported that procyanidin oligomers selectively promote growth of murine hair epithelial cells in vitro and stimulate […]

Lack of effects of a lyposterolic extract of Serenoa repens on plasma levels of testosterone, follicle-stimulating hormone, and luteinizing hormone

Abstract: Twenty men, aged 50 to 75 years (mean, 67 years), suffering from benign prostatic hypertrophy received 160 mg of […]

Comparison of finasteride (Proscar) and Serenoa repens (Permixon) in the inhibition of 5-alpha reductase in healthy male volunteers

Abstract: A total of 32 healthy male volunteers (age range 20-30 years) were enrolled in a 1-week open, randomized, placebo-controlled […]

Inhibition of the activity of ‘basic’ 5 alpha-reductase (type 1) detected in DU 145 cells and expressed in insect cells

Abstract: The purpose of this study was 2-fold: (1) to identify the 5 alpha-reductase (5 alpha-R) isozyme(s) present in DU […]

Cations inhibit specifically type I 5 alpha-reductase found in human skin

Abstract: Steroid 5 alpha-reductase catalyzes the reduction of testosterone into the very potent androgen dihydrotestosterone. Previously, we showed that human […]

The effect of Permixon on androgen receptors

Abstract: Permixon, the liposterolic extract of the plant Serenoa Repens is a recently introduced drug for the treatment of benign prostatic hyperplasia. […]

Comparison of finasteride (Proscar), a 5 alpha reductase inhibitor, and various commercial plant extracts in in vitro and in vivo 5 alpha reductase inhibition

Abstract: Human prostate was used as a source of 5 alpha reductase. Compounds were incubated with an enzyme preparation and […]

Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid

Abstract: The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an […]
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