mTORGRADE C
Rapamycin
Sirolimus
The most-studied lifespan-extending compound in animals; human longevity data still emerging.
- Status
- Rx
- Typical cost
- $30–$150 / mo
The core database
Longevity drugs, graded.
Every compound people ask about — what it does, what the human evidence actually shows, and how people access it. Conservative by design.
Evidence
12 of 12 entries · select up to 3 to compare
metabolicGRADE B
Metformin
Decades-old diabetes drug studied for healthy aging; strong safety record, unproven for longevity in non-diabetics.
- Status
- Rx
- Typical cost
- $5–$20 / mo
metabolicGRADE C
Acarbose
A carb-blocking diabetes drug that robustly extends lifespan in male mice.
- Status
- Rx
- Typical cost
- $20–$60 / mo
GLP-1GRADE A
Semaglutide
Ozempic / Wegovy
GLP-1 agonist with hard-outcome RCT data: weight loss and reduced cardiovascular events.
- Status
- Rx
- Typical cost
- $200–$1,300 / mo
GLP-1GRADE A
Tirzepatide
Mounjaro / Zepbound
Dual GIP/GLP-1 agonist producing the largest average weight loss of any approved drug.
- Status
- Rx
- Typical cost
- $400–$1,200 / mo
metabolicGRADE A
SGLT2 inhibitors
Empagliflozin (Jardiance)
Glucose-lowering drugs with strong heart and kidney outcome data, even outside diabetes.
- Status
- Rx
- Typical cost
- $30–$600 / mo
NAD+/mitochondrialGRADE C
NAD+ / NMN
Nicotinamide mononucleotide, NR
Precursors that reliably raise blood NAD+; meaningful human health benefits remain unproven.
- Status
- Supplement
- Typical cost
- $40–$150 / mo
otherGRADE C
Low-dose naltrexone
LDN
Tiny doses of an addiction drug, studied for chronic pain and inflammation.
- Status
- Rx / compounded
- Typical cost
- $25–$60 / mo
hormoneGRADE B
Testosterone replacement therapy
TRT
Effective for diagnosed hypogonadism; the TRAVERSE trial eased cardiovascular concerns.
- Status
- Rx
- Typical cost
- $100–$300 / mo
senolyticGRADE D
Dasatinib + Quercetin
D+Q
The first senolytic combination; striking in mice, very early in humans.
- Status
- Rx
- Typical cost
- $100–$400 / course
otherGRADE D
Taurine
An amino acid that declines with age; extended lifespan in mice, human trials pending.
- Status
- Supplement
- Typical cost
- $10–$25 / mo
otherGRADE D
Spermidine
A dietary polyamine that induces autophagy; human evidence is observational.
- Status
- Supplement
- Typical cost
- $30–$70 / mo
Not medical advice — talk to a licensed clinician. Content is educational, reflects published literature, and is not a recommendation to start, stop or change any treatment.